Diabetes & Obesity
Type 2 Diabetes Mellitus (T2DM):
Pathophysiology and Therapeutic Strategy
Overview
Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by elevated blood glucose levels (hyperglycemia) resulting from insulin resistance and relative insulin deficiency.
Etiology
The development of T2DM is influenced by a combination of genetic predisposition and lifestyle factors, including:
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Poor dietary habits
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Low physical activity
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Obesity, particularly visceral obesity, which represents the primary risk factor for disease onset
Clinical Manifestations
Typical symptoms of Type 2 Diabetes Mellitus include:
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Excessive thirst and frequent urination
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Persistent fatigue
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Blurred vision
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Delayed wound healing
Complications
If not adequately controlled, T2DM may lead to severe systemic complications, including:
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Cardiovascular diseases (atherosclerosis, myocardial infarction, stroke)
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Nephropathy (progressive kidney damage)
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Neuropathy (peripheral nerve damage)
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Retinopathy (vision impairment and potential blindness)
Obesity and Its Role
Obesity is defined as excessive accumulation of adipose tissue that disrupts metabolic balance and adversely affects overall health.
It plays a central role in the development of insulin resistance and the metabolic dysregulation associated with Type 2 Diabetes Mellitus.
Project Strategy: Therapeutic Normalization of Metabolic Processes and Glycemic Control
The project aims to develop a therapeutic solution that ensures effective regulation of glucose metabolism, restoration of insulin sensitivity, and sustainable weight management through a multi-target approach encompassing the following mechanisms:
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Stimulation of insulin secretion
Enhances glucose-dependent insulin release, reducing hyperglycemia while minimizing the risk of hypoglycemia. -
Slowing of gastric emptying
Delays gastric emptying to moderate postprandial glucose spikes, promoting gradual absorption and stable glycemic control. -
Appetite reduction
Modulates central appetite-regulating pathways, reducing hunger and contributing to clinically meaningful weight loss. -
Improved insulin sensitivity
Increases peripheral tissue responsiveness to insulin, enabling efficient cellular glucose uptake and utilization.
For more information,
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